研究業績

Takeda R., Ishii R., Parvin S., Shiozawa A., Nogi T., and Sasaki Y.  Novel presynaptic assay system revealed that metformin ameliorates exaggerated synaptic release and Munc18-1 accumulation in presynapses of neurons from Fragile X syndrome mouse model.  Neurosci. Lett. 810:137317 (2023). [PubMed]

Casingal C. R., Kikkawa T., Inada H., Sasaki Y., and Osumi N.  Identification of FMRP target mRNAs in the developmental brain: FMRP might coordinate Ras/MAPK, Wnt/β-catenin, and mTOR signaling during corticogenesis.  Mol. Brain 13:167 (2020). [PubMed]

Sasaki Y.  Local Translation in Growth Cones and Presynapses, Two Axonal Compartments for Local Neuronal Functions.  Biomolecules, 10:668 (2020). [PubMed]

Takabatake M., Goshima Y., and Sasaki Y.  Semaphorin-3A Promotes Degradation of Fragile X Mental Retardation Protein in Growth Cones via the Ubiquitin-Proteasome Pathway.  Front. Neural Circuits, 14:5 (2020). [PubMed]

Parvin S., Takeda R., and Sasaki Y.  Presynapse formation assay using presynapse organizer beads and "Neuron Ball" culture.  J. Vis. Exp. (150): e59893 (2019). [PubMed]

Parvin S., Takeda R., Sugiura Y., Neyazaki M., Nogi T., and Sasaki Y.  Fragile X mental retardation protein regulates accumulation of the active zone protein Munc18-1 in presynapses via local translation in axons during synaptogenesis.  Neurosci. Res. 146: 36-47 (2019). [PubMed]

Goshima Y., Yamashita N., Nakamura F., and Sasaki Y.  Regulation of dendritic development by Semaphorin 3A through novel intracellular remote signaling.  Cell Adh. Migr. 10: 627-640 (2016). [PubMed]

Sasaki, Y.*#, Gross, C.#, Xing, L., Goshima, Y., and Bassell G. J*.  Identification of axon-enriched MicroRNAs localized to growth cones of cortical neurons.  Dev. Neurobiol. 74: 397-406 (2014). (*co-corresponding authors, #equal contribution) [PubMed]

Yamashita, N., Usui, H., Nakamura, F., Chen, S., Sasaki, Y., Hida, T., Suto, F., Taniguchi, M., Takei K., Goshima, Y.  Plexin-A4-dependent retrograde semaphorin 3A signalling regulates the dendritic localization of GluA2-containing AMPA receptors.  Nat. Commun. 5: 3424 (2014).[PubMed]

Iketani, M., Iizuka, A., Sengoku, K., Kurihara, Y., Nakamura, F., Sasaki, Y., Sato, Y., Yamane, M., Matsushita, M., Nairn, A. C., Takamatsu, K., Goshima, Y., and Takei K.  Regulation of neurite outgrowth mediated by localized phosphorylation of protein translational factor eEF2 in growth cones.  Dev. Neurobiol. 73: 230-246 (2013). [PubMed]

Hida, T., Yamashita, N., Usui, H., Nakamura, F., Sasaki, Y., Kikuchi, A., and Goshima, Y.  GSK3β/Axin-1/β-catenin complex is involved in Semaphorin3A Signaling.  J. Neurosci, 32: 11905-11918. (2012). [PubMed]

Goshima, Y., Sasaki, Y., Yamashita, N., and Nakamura, F.  Class 3 semaphorins as a therapeutic target.  Expert Opin. Ther. Targets, 16: 933-944 (2012). [PubMed]

Han, L., Wen, Z., Lynn, R. C., Baudet, M. L., Holt, C. E., Sasaki, Y., Bassell, G. J., and Zheng, J. Q.  Regulation of chemotropic guidance of nerve growth cones by microRNA.  Mol. Brain, 4:40 (2011). [PubMed]

Yamashita, N., Mosinger, B., Roy, A., Miyazaki, M., Ugajin, K., Nakamura, F., Sasaki, Y., Yamaguchi, K., Kolattukudy, P., and Goshima, Y.  CRMP5 (Collapsin Response Mediator Protein 5) Regulates Dendritic Development and Synaptic Plasticity in the Cerebellar Purkinje Cells.  J. Neurosci, 31: 1773-1779 (2011). [PubMed]

Sasaki, Y., Welshhans, K., Wen, Z., Yao, J., Xu, M., Goshima, Y., Zheng, J. Q., and Bassell, G. J.  Phosphorylation of zipcode binding protein is required for BDNF signaling of local β-actin synthesis and growth cone turning.  J. Neurosci, 30: 9349-9358 (2010). (Selected in “This Week in The Journal”.) [PubMed]

Li, C., Bassell, G. J.*, and Sasaki, Y.*  Fragile X Mental Retardation Protein is involved in protein synthesis-dependent collapse of growth cones induced by Semaphorin-3A.  Front. Neural Circuits, 3:11 (2009).  (*co-corresponding authors) [PubMed]

Uchida, Y., Ohshima, T., Yamashita, N., Ogawara, M., Sasaki, Y., Nakamura, F., and Goshima, Y.  Semaphorin3A signaling mediated by Fyn-dependent tyrosine phosphorylation of collapsin response mediator protein 2 at tyrosine 32.  J. Biol. Chem. 284: 27393-27401 (2009). [PubMed]

Santangelo, P. J., Lifland A. W., Curt, P., Sasaki, Y., Bassell, G. J., Lindquist, M. E., and Crowe Jr, J. E.  Single molecule–sensitive probes for imaging RNA in live cells.  Nat. Methods, 6: 347-349 (2009). [PubMed]

Willis, D. E, van Niekerk, E. A., Sasaki, Y., Mesngon, M., Merianda, T. T. , Williams, G. G., Kendall, M., Smith, D. S., Bassell, G. J. , and Twiss, J. L.  Extracellular stimuli specifically regulate localized levels of individual neuronal mRNAs.  J. Cell. Biol. 178: 965-980 (2007). [PubMed]

Yao, J., Sasaki, Y., Wen, Z., Bassell, G., J., and Zheng, J., Q.  An essential role for beta-actin mRNA localization and translation in Ca2+-dependent growth cone guidance.  Nat. Neurosci. 9: 1265-1273 (2006). [PubMed]

Morita, A., Yamashita, N., Sasaki, Y., Uchida, Y., Nakajima, O., Nakamura, F., Yagi, Y., Taniguchi, M., Usui, H., Katoh-Semba, R., Takei, K., and Goshima, Y.  Regulation of Dendritic Branching and Spine Maturation by Semaphorin3A-Fyn Signaling.  J. Neurosci. 26: 2971-2980 (2006).[PubMed]

Saito-Shibakawa, Y., Sasaki, Y., Goshima, Y., Echigo, N., Kamiya, Y., Kurahashi, K., Yamada, Y., and Andoh, T.  Effects of ketamine and propofol on inflammatory responses of primary glial cell cultures stimulated with lipopolysaccharide.  Br. J. Anaesth. 95:803-810 (2005). [PubMed]

Uchida, Y., Ohshima, T., Sasaki, Y., Suzuki, H., Yanai, S., Yamashita, N., Nakamura, F., Takei, K., Ihara, Y., Mikoshiba, K., Kolattukudy, P., Honnorat J., and Goshima, Y.  Semaphorin-3A signaling is mediated via sequential Cdk5 and GSK3b phosphorylation of CRMP2: implication of common phosphorylating mechanism underlying axon guidance and Alzheimer’s disease.  Genes Cells, 10: 165-179 (2005). [PubMed]

Li, C., Sasaki, Y., Takei, K., Yamamoto, H., Shouji, M., Sugiyama, Y., Kawakami, T., Nakamura, F., Yagi, T., Ohshima, T., and Goshima, Y.  Correlation between semaphorin3A-induced facilitation of axonal transport and local activation of a translation initiation factor eukaryotic translation initiation factor 4E.  J. Neurosci. 24: 6161-6170 (2004). [PubMed]

Cheng, Q., Sasaki, Y., Shoji, M., Sugiyama, Y., Tanaka, H., Nakayama, T., Mizuki, N., Nakamura, F., Takei, K., and Goshima, Y.  Cdk5/p35 and Rho-kinase mediate ephrin-A5-induced signaling in retinal ganglion cells.  Mol. Cell. Neurosci. 24: 632-645 (2003). [PubMed]

Endo, M., Ohashi, K., Sasaki, Y., Goshima, Y., Niwa, R., Uemura, T., and Mizuno, K.  Control of Growth Cone Motility and Morphology by LIM-kinase and Slingshot via Phosphorylation and Dephosphorylation of Cofilin.  J. Neurosci. 23: 2527-2537 (2003). [PubMed]

Sasaki, Y.*, Cheng, C., Uchida, Y., Nakajima, O., Ohshima, T., Yagi, T., Taniguchi, M., Nakayama, T., Kishida, R., Kudo, Y., Ohno, S., Nakamura, F., and Goshima, Y*.  Fyn and Cdk5 mediate semaphorin-3A signaling, which is involved in regulation of dendrite orientation in cerebral cortex.   Neuron 35: 907-920 (2002). (*co-corresponding author) [PubMed] [Faculty of 1000]

Goshima, Y., Ito, T., Sasaki, Y. and Nakamura, F.  Semaphorins as signals for cell repulsion and invasion.  J. Clin. Invest., 109: 993-998 (2002). [PubMed]

Yamanashi, K., Miyamae, T., Sasaki, Y., Maeda, M., Hirano, H., Misu, Y., and Goshima, Y.  Involvement of nitric oxide production via kynurenic acid-sensitive glutamate receptors in DOPA-induced depressor responses in the nucleus tractus solitarii of anesthetized rats.  Neurosci. Res., 43: 231-238 (2002). [PubMed]

Aizawa, H., Wakatsuki, S., Ishii, A., Moriyama, K., Sasaki, Y., Ohashi, K., Sekine-Aizawa, Y., Sehara-Fujisawa, A., Mizuno, K., Goshima, Y., and Yahara, I.  Phosphorylation of cofilin by LIM-kinase is necessary for semaphorin 3A-induced growth cone collapse.  Nat. Neurosci, 4: 367-373 (2001). [PubMed]

Arai, N., Furukawa, N., Miyamae, T., Goshima, Y., Sasaki, Y., Ohshima, E., Suzuki, F., Fujita, K., and Misu, Y.  DOPA cyclohexyl ester, a competitive DOPA antagonist, protects glutamate release and resultant delayed neuron death by transient ischemia in hippocampus CA1 of concious rats.  Neurosci. Lett., 299: 213-216 (2001). [PubMed]

Sugaya, Y., Sasaki, Y., Goshima, Y., Kitahama, K., Kusakabe, T., Miyamae, T., Kato, T., and Misu, Y.  Autoradiographic studies using L-[14C] and [3H]DOPA reveal regional Na+-dependent uptake of the neurotransmitter candidate L-DOPA in the central nervous system.  Neuroscience, 104: 1-14 (2001). [PubMed]

佐々木　幸生、五嶋　良郎　神経軸索における局所翻訳制御と機能調節　細胞工学 31: 677-682, (2012).

佐々木　幸生、Bassell, G., J.　RNAと神経疾患　Clin. Neurosci. 24: 950-951 (2006).

佐々木　幸生、五嶋　良郎　神経軸索誘導の分子機序　－セマフォリンファミリーを中心に－　Med. Sci. Digest, 28: 525-529 (2002).

佐々木　幸生、五嶋　良郎　神経ガイド分子セマフォリン-3AはFyn-Cdk5キナーゼカスケードを介して大脳皮質神経回路網形成を制御する　細胞工学  21: 1324-1325 (2002).

佐々木　幸生、五嶋　良郎　ガイダンス分子のシグナル伝達　細胞工学 20: 530-537 (2001).

佐々木幸生、五嶋良郎　第１部22章「セマフォリンシグナリング」　イラストで徹底理解するシグナル伝達キーワード事典（山本　雅、仙波　憲太郎、山梨　祐司　編）pp77-79、羊土社、東京 (2012).

Goshima, Y., Sasaki, Y., Uchida, Y., Yamashita, N., and Nakamura, F.  CRMP family protein: Novel targets for Cdk5 that regulates axon guidance, synapse maturation, and cell migration.  In: Cyclin Dependent Kinase 5 (Cdk5) (Ip, N., Y., and Tsai, L.-H., eds.) pp. 9-24, Springer Science+Business Media, New York (2008). [Amazon]

Sasaki, Y., Goshima, Y., and Misu, Y.  Active uptake system of L-DOPA in CNS.  In: Neurobiology of DOPA As a Neurotransmitter (Misu, Y., and Goshima, Y., eds.) pp. 35-46, Taylor & Francis (CRC Press), Abingdon (2005). [Amazon]

五嶋良郎、佐々木幸生　第3部6章「神経軸索ガイド分子の反発・誘引活性と細胞内機序」　細胞骨格と細胞運動-その制御のメカニズム-（竹縄　忠臣　編）pp207-215、シュプリンガー・フェアラーク東京、東京 (2002).